Immunohistochemical ferritin in hepatocellular carcinoma.

Hepatocellular Carcinoma in Sheep

Hepatocellular carcinoma in a sheep

At necropsy of a five-year-old sheep, a pear shaped, lobular yellow-brownish mass measuring about 12 ×15 × 20 cm was found to involve the right hepatic lobe. Microscopic examination revealed two trabecularand solid patterns of neoplastic hepatocytes. In solid pattern, there were numerous tumoral giant cells thatcontain one or more large hyperchromatic bizarre-shaped nuclei scattered among clust...

SIRT7, H3K18ac, and ELK4 Immunohistochemical Expression in Hepatocellular Carcinoma

BACKGROUND SIRT7 is one of the histone deacetylases and is NAD-dependent. It forms a complex with ETS-like transcription factor 4 (ELK4), which deacetylates H3K18ac and works as a transcriptional suppressor. Overexpression of SIRT7 and deacetylation of H3K18ac have been shown to be associated with aggressive clinical behavior in some cancers, including hepatocellular carcinoma (HCC). The presen...

Immunohistochemical analysis in hepatocellular carcinoma: does age matter?

Hepatocellular carcinoma (HCC) is one of the most common malignant neoplasms in the world, and although it is considerably less common in the United States, an increase in the number of cases has been observed during the past 2 decades. 1 Studies from western Europe and Japan also have documented a rising trend in the incidence and mortality of HCC. 2 The incidence of HCC seems to be related to...

The Histomorphological and Immunohistochemical Diagnosis of Hepatocellular Carcinoma

Hepatocellular carcinoma is one of the most common malignancies worldwide, and its incidence is growing in association with viral and nonviral chronic liver diseases (Sherman M, 2010). Hepatocellular carcinoma is a lethal cancer, and improved survival relies on the detection of early tumors smaller then 2 cm, which are less likely to have dissemination (Di Tommaso, 2011). The diagnosis of hepat...